1. The common-sense approach to resolving runtime issue is to first locate the file or files that caused the error. Was it an Excel file? Word file? Check with the vendor of the application for a fix or patch. If the error occurred in an Excel spreadsheet, go to Microsoft's Help amp; Support link and locate the 'hotfix.'
2. Try to uninstall then reinstall the targeted application by going to the 'Control Panel,' then 'Add/Remove Programs.'

3. Locate then run a good registry cleaner utility, such as RegClean, to get rid of the corrupted files/keys, then run your antivirus software to do a full sweep of your computer.